How do you define Inflammation? The complex physiological reaction known as inflammation is brought on by noxious stimuli like pathogens, harmed cells, or irritants. The inflammatory response of the body aids in tissue repair and healing while serving as an essential defense mechanism against infection and injury. Underlying factors responsible for Inflammation: Infection by microorganisms Injury, such as trauma, surgery Chronic stress Autoimmune disorders such as rheumatoid arthritis Environmental toxins, such as pollution, cigarette smoke Allergy Mechanism: When immune cells like mast cells, macrophages, and dendritic cells are activated, they release a range of pro-inflammatory mediators like cytokines, chemokines, and prostaglandins. This starts the inflammatory response. These mediators encourage immune cells to migrate into the afflicted tissue to remove the harmful stimuli and aid in attracting additional immune cells to the site of inflammation. Immune cells work to remove any