What is double crush syndrome? Double crush syndrome is a medical condition that can be difficult to diagnose and may be overlooked or misunderstood. It occurs when a nerve is compressed or irritated at two or more points along its pathway, leading to symptoms in areas where the same nerve innervates. This condition was first described in the 1970s and has since been recognized as a potential cause of pain, weakness, numbness, and tingling, among other symptoms. It is often seen in individuals who perform repetitive movements with their hands or other body parts and can be exacerbated by underlying conditions such as diabetes or arthritis. Etiology & Pathophysiology Double crush syndrome can potentially develop in any part of the body where a nerve pathway exists, but it is most frequently observed in the upper extremities, especially in the hands and arms. It is often seen in individuals who perform repetitive movements with their hands, such as musicians, computer users, or at