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PARKINSON'S DISEASE

  INTRODUCTION Parkinson's disease (PD), a neurodegenerative disorder, intricately weaves its way into the lives of millions globally, presenting a myriad of challenges for both individuals and healthcare professionals. This comprehensive exploration aims to unravel the layers of PD, delving into its complex etiology, intricate pathophysiological processes, multifaceted symptoms, diagnostic intricacies, and evolving management strategies. ETIOLOGY Genetic Factors: A subset of Parkinson's cases (15-25%) exhibits a familial predisposition, implicating specific genes like SNCA, LRRK2, and Parkin. These genetic mutations contribute to the onset of familial Parkinson's disease. Environmental Factors: Pesticide and herbicide exposure, industrial chemicals, and rural living have been associated with an elevated risk of PD. The intricate interplay between genetic susceptibility and environmental toxins remains an active area of research. Age-Related Factors: Parkinson's disease